¹¹¹In Zevalin Imaging: Purpose

• To verify the expected biodistribution

• R/O rare cases of altered biodistribution

• Not to diagnose the extent of NHL

Data Acquisition for In-111 Zevalin

• Dual or single head gamma camera system

• Medium energy collimator(s)

• 172 and 247 keV with 15% window

• 256 x 1024 matrix

• Speed (dependent on time after injection)

• 10 cm/min (20 minute scan) at 2 - 24 hours

• 7 - 10 cm/min (30 minute scan) at 48 - 72 hours

• 5 - 7 cm/min (40 minute scan) at 90 - 120 hours (optional)

Expected Biodistribution

Anterior Posterior	Anterior Posterior	Anterior Posterior
4-6 Hrs	64-70 Hrs	138-142 Hrs

Representative Patient: ¹¹¹In-Labeled Zevalin^® Monoclonal Antibody Imaging

4 hour	66 hours		139 hours
		Abdominal SPECT
		Abdominal CT

Altered Biodistribution Image


Median Y-90 Zevalin Radiation Absorbed Doses to Organs and Tumor