Principles of Radioimmunotherapy

• Targeted delivery of radiation
• Greater exposure of tumors vs. surrounding organs by virtue of the selectivity of the carrier antibody
• Potential for continuous exposure of tumor cells
• Anti-tumor mechanisms of the antibody

Juweid ME. J Nucl Med 2002;43:1507-1529. Kaminski MS et al. Blood 2000;96:1259-1266.

 

Rationale for Radioimmunotherapy of Lymphoma

• High sensitivity of lymphomas to radiation
• Abundant and well-characterized surface antigens
• Multiple MAbs available
• Promising clinical results with unconjugated antibodies (Rituximab)