Quiz: Radiopharmaceuticals

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TEST: Radiopharmaceuticals

1. Which ONE of the following statements is true?:

Tc-99m Sestamibi has a short biological half-life in the heart

Tc-99m Teboroxime has a long biological half-life in the heart

Tc-99m HMPAO has a long biological half-life in the brain

The t_biol of Tc-99m HSA in the blood pool is >Tc-99m RBC's

2. The renal agent Tc-99m MAG3 is cleared from the body by the following route...:

Glomerular filtration 100%

Tubular binding/glomerular filtration/tubular secretion, 20/40/40

Predominantly tubular binding

Tubular secretion/glomerular filtration 80/20

3. The mechanism of radiopharmaceutical localization in a ventilation study is...?:

Phagocytosis

Compartmental Localization

Active Transport

Capillary Blockade

4. The mechanism of uptake of radiopharmaceutical in liver-spleen scanning is...?:

Particulate blockade

Hydrolysis of the colloid particles by the hepatocytes

Phagocytosis by the RE system

None of the above

5. Consider the following radiopharmaceuticals: Tc-99m pertechnetate, I-123 sodium iodide, I-125 sodium iodide, and I-131 sodium iodide. Which of them is/are suitable for thyroid imaging?

All of Them

None of Them

Tc-99m pertechnetate and I-123 sodium iodide only

Tc-99m pertechnetate, I-123 sodium iodide, and I-131 sodium iodide only

6. Which of the following radiopharmaceuticals is suitable for blood pool scanning?:

Tc-99m sulfur colloid

Tc-99m tagged DTPA

Tc-99m tagged red blood cells

None of the above

7. The optimal time for detection of acute myocardial infarction by infarct avid agents is:

6 hours after onset of symptoms

24 to 72 hours after onset of symptoms

During chest pain

One week after onset of symptoms

8. The ideal diagnostic radiopharmaceutical has an effective half life of:

Of 1 day

1½ times the biological half-life

Of 6 hours

1 to 1½ times the length of time necessary to complete the test

9. Which ONE of the following statements regarding hepatobiliary agents is True?:

Typical injected dose is 3-8 mCi

In an emergency, one could substitute Tc Sulfur Colloid for Tc-DISIDA for use in hepatobiliary imaging

If gallbladder accumulation of the DISIDA first appears on scan at 90 minutes post injection, this is a normal study

The -IDA ending on DISIDA stands for -imidodiacetic acid

10. Within what % of the prescribed dose must the calibrated dose be?

10%

25%

50%

11. Which of the following IS NOT a characteristic of the ideal diagnostic radiopharmaceutical?

Pure gamma emitter

100< gamma energy <250 KEV

Effective half life = 5 X test duration

High target to non-target ratio

12. Which of the following IS a characteristic of the ideal therapeutic radiopharmaceutical?

Pure gamma emitter

100< gamma energy <250 KEV

Effective half life = 1.5 X test duration

High target to non-target ratio

13. Which of these statements about radiopharmaceuticals and radiochemicals is correct??

Radiochemicals have undergone a very lengthy and expensive regulatory process

Radiochemicals have undergone extensive chemical and physical testing (pH, isotonicity, and chemical parameters)

Radiopharmaceuticals must undergo a regulatory process to guarantee safety and efficacy

Radiopharmaceuticals have been tested in animals, but not in humans, prior to release of the product for sale.

14. Which one of the following series includes only generator produced radionuclides

Tc-99m, Ga-68, Kr-81m, Rb-82, and In-113m

Tc-99m, C-11, N-13, Cr-51

Tc-99m, Co-57, Ga-67, In-111, and Tl-201.

Tc-99m, Xe-133, Mo-99, and I-131

15. Which one of the following series includes only cyclotron produced radionuclides

Ga-68, Kr-81m, Rb-82, Tc-99m, and In-113m

Cr-51, Ga-67, Tc-99m, I-131

Co-57, Ga-67, In-111, I-123, and Tl-201

Xe-133, Mo-99, and I-131

16. Which one of the following statements regarding pyrogens in radiopharmaceuticals is true?

When injected intrathecally, pyrogens are estimated to be 1000 times as potent as when injected intravenously

The Limulus Amebacyte Lysate test is the least sensitive method of detecting pyrogens

The rabbit test is the most sensitive method of detecting pyrogens

The rabbit test is performed on serum samples

17. FDA regulations requires which one of the following:

Every dose of every radiopharmaceutical must be calibrated before administration to the patient

The administered dose must be within ±20% of the prescribed dose

Doses received from a central radiopharmacy do not have to be calibrated

Short-lived cyclotron products are exempted from calibration

18. Which one of the following series includes only cyclotron produced radionuclides

Ga-68, Kr-81m, Rb-82, Tc-99m, and In-113m

Cr-51, Ga-67, Tc-99m, I-131

Co-57, Ga-67, In-111, I-123, and Tl-201

Xe-133, Mo-99, and I-131

19. Consider the following radiopharmaceuticals: Tc-99m pertechnetate, I-123 sodium iodide, I-131 sodium iodide, and Tc-99m Myoview. Which of them is/are suitable for thyroid imaging?

All of them

None of them

Tc-99m pertechnetate and I-123 sodium iodide only

Tc-99m pertechnetate, I-123 sodium iodide, and I-131 sodium iodide only

20. For a patient with known pulmonary hypertension, the number of particles of Tc-MAA should be limited to ...?

50,000

150,000

300,000

500,000

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