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Mechanisms of Localization
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Test: Mechanisms of Localization of Radiopharmaceuticals
1. For Tc-MAA localization in the lungs, the mechanism is based upon... Phagocytosis of the albumin particles Chemisorption Capillary filtration Microembolization of capillaries using precipitated human serum albumin particles
2. The uptake of Tc-MDP in bone tissue is based upon... Passive diffusion and exchange with hydroxide ions Surface absorption of the labeled phosphonate on hydroxyapatite crystals Phagocytosis by the bone matrix Metabolic trapping 3. 18F-FDG localizes in malignant tumors because... It undergoes phagocytosis in the mitochondria It is a fatty acid analog and is readily taken up by tumors It undergoes metabolic trapping It is organified by a fluorination reaction
4. The mechanism of localization of In-111 Octreoscan in an insulinoma is called... Antigen-antibody reaction Metabolic trapping Chemisorption Receptor Binding 5. Imaging of the airways in the lungs is an example of... Chemisorption Simple diffusion Compartmental Localization Active transport
6. Imaging of tubular secretory function of the kidneys is an example of... Chemisorption Simple diffusion Compartmental Localization Active transport
7. Uptake of radioiodide by the thyroid is an example of... Chemisorption Simple diffusion Compartmental Localization Active transport
8. The transfer of Xe-133 gas across lipid membranes in the lungs into the bloodstream is called... Chemisorption Simple diffusion Compartmental Localization Active transport
9. F-18 NaF may be used for bone imaging. Which of the following mechanisms describes its uptake in bone tissue? Chemisorption Simple diffusion Exchange diffusion Compartmental Localization Active transport
10. For visualization of prostate cancer metastases following injection of In-111 ProstaScint, the operating mechanism is... Antigen-Antibody Reaction Metabolic trapping Chemisorption Receptor binding Active transport
11. Which one of the following is NOT an example of Compartmental Localization? Pulmonary ventilation study w/ Xe-133 gas Cisternogram with In-111 DTPA Hepatobiliary study with Tc-99m disofenin Voiding cystogram with Tc-99m SC 12. Which of the following represents Active Transport? Uptake and organification of radioiodide in the thyroid gland Uptake of Tc-99m MAG by the kidneys Uptake of Rb-82 ion by the heart All of the Above
13. Which of the following represents Physicochemical Adsorption? a.) Thrombosis imaging with Tc-99m AcuTect b.) Spleen imaging w/ damaged labeled RBCs c.) Bone imaging with Tc-99m labeled phosphate based bone agents a and c only all of the above 14. Tc-99m MAA is used to assess pulmonary perfusion. Which ONE of the following statements is FALSE? The typical injection of MAA particles causes microembolization of ~350,000 capillaries The number of particles to be administered is reduced for a patient with pulmonary hypertension Approximately 1% of all capillaries in the lungs is occluded by the typical injection The biological half-life of Tc-MAA in the lungs is approximately 8 hours
15. Which of the following represents Phagocytosis? Uptake and organification of radioiodide in the thyroid gland Uptake of Tc-MAA in the lungs Spleen uptake of denatured red cells Liver uptake of F-18 FDG Liver uptake using 99mTc sulfur colloid
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