After reviewing this tutorial, the user should be able to list the various types of impurities found in the eluate collected from the Mo-99/Tc-99m generator and give an example of each; should be able to identify the various classes of impurities found in radiopharmaceuticals and give an example of each; should be able to describe in detail how QC testing is performed on the eluate and on Tc-99m radiopharmaceuticals; should be able to state the specifications for each of these tests and what action is required if there is a test failure; should be able to list the 4 QC tests performed on a dose calibrator and required frequency of performance; should be able to describe how each test is performed, state the legal specification, and describe the action required if there is a test failure; should be able to state the difference between agreement states and non-agreement states; should know the basics of licensure by the NRC and State regulatory agencies; should be able to list the various requirements for maintaining log books in the lab and the required frequency of entry; should be familiar with basic rules of radiation safety, e.g., to describe what precautions and action must be taken when there is a spill or contamination is found on a technologist's hands; and should be able to define "misadministration" according to the new rules, and to state what one must do to document and report the occurrence.

bullet

RATIONALE FOR PERFORMING QUALITY CONTROL
bullet

For certain procedures, IT'S THE LAW.
bulletNon-Diagnostic Study ==> Procedure must be repeated; increased radiation dose and patient discomfort; delayed diagnosis

 

bulletCRITERION: You must be able to answer "yes" to the question, "Would I inject this into my mother?"
bulletImpurities
bulletClassification
bulletDetection of Impurities

 

bulletQC Testing of a Mo/Tc Generator
bulletFrequency Specifications
bulletQC Test Procedures for Mo/Tc Generator
bulletMo-99 Breakthrough
bulletAluminum Ion Breakthrough
bulletFree Tc

 

bulletQC Testing in Radiopharmaceuticals
bulletTypes of Impurities
bulletThin Layer Chromotography Systems of Tc-99m Compounds.
bulletTc-99m Chromotography: Separation on Strip
bulletThin Layer Chromotography Systems:Tc-99m Hepatobiliary Agents
bulletExceptions
bulletStrip Design
bulletMigration Patterns of Tc-MDP

 

bulletQuality Control Of Dose Calibrators
bulletFrequency Specifications
bulletGeometry
bulletAccuracy
bulletConstancy
bulletLinearity
bullet Specifications: Dose Calibrator QC Tests
bulletFull Width Half-Maximum Value